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phenobarbital raises toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. CYP3A4 inducers may perhaps raise the metabolism of ifosfamide to its Energetic alkylating metabolites.Barbiturates tend not to impair standard hepatic perform but are shown to induce liver microsomal enzymes, As a result